Rosenmund reduction
The Rosenmund reduction is a chemical reaction that reduces an acid halide to an aldehyde using hydrogen gas over palladium-on-carbon poisoned with barium sulfate.[1][2][3] The reaction was named after Karl Wilhelm Rosenmund.
The catalyst must be poisoned because otherwise the catalyst is too active and will reduce the acid chloride to a primary alcohol.
Diisobutylaluminium hydride (DIBALH) can also reduce acid chlorides to aldehydes.
See also
References
- ^ Rosenmund, K. W. (1918). "Über eine neue Methode zur Darstellung von Aldehyden. 1. Mitteilung". Chemische Berichte 51: 585–593. doi:10.1002/cber.19180510170.
- ^ Rosenmund, K. W., Zetzsche, F. (1921). "Über die Beeinflussung der Wirksamkeit von Katalysatoren, 1. bis 5". Chemische Berichte 54 (3): 425–437; 638–647; 1092–1098; 2033–2037; 2038–2042. doi:10.1002/cber.19210540310.
- ^ Mosettig, E.; Mozingo, R. Org. React. 1948, 4, 362. (Review)
Further reading